Novel Synthesis of Hydrazide-hydrazone and Their Uses for the Synthesis 1,3,4-oxadiazine, 1,2,4-triazine, Pyrazole and Pyridazine Derivatives with Antimicrobial and Antifungal Activities
نویسندگان
چکیده
The reaction of the cyanoacetylhydrazine (1) with α-bromoketones (2a-c) gave the hydrazide-hydrazone derivatives 3a-c. The latter compounds underwent ready cyclization when heated in sodium ethoxide to form the 1,3,4-oxadiazine derivatives 4a-c. The reaction of 3a with hydrazines gave the 1,3,4-triazine derivatives 7a,b. Compounds 3a-c and 7a,b underwent some heterocyclizations when treated with some reagents to afford coumarin, 1,2,4-triazine, pyridazine and pyrazole derivatives. The antimicrobial and antifungal activities of the newly synthesized products were measured which showed that most of have high activities.
منابع مشابه
Hydrazide-Hydrazones in the Synthesis of 1,3,4-Oxadiazine, 1,2,4-Triazine and Pyrazole Derivatives with Antitumor Activities
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